Premarital Screening for Thalassemia Among Young Adults: A Study in Zabol, Sistan and Baluchistan Province of Iran

Introduction: There is a high prevalence of hemoglobinopathies, including thalassemia, in Sistan and Baluchistan province Iran. It important to appropriately screen young adults control the birth new cases thalassemia. In many less-equipped centers, this practice only relies on cell blood count. This study investigated hematological parameters referring Central Laboratory Sistan, Zabol, for premarital screening Methods: was descriptive cross-sectional conducted Iran from August 2020 2021. Complete count (CBC) 2926 were collected using Sysmex KX-21 device compared with available reference intervals according Clinical Standard Institute. Results: The means women’s men’s age 38.84±16.32 36.64±14.14 years, respectively. average values each parameter studied population red (RBC) (4.78±0.55), hemoglobin (13.19±2.46 g/dL), hematocrit (40.11±3.57%), mean corpuscular volume (MCV) (85.16±28.33), neutrophil (52.12±9.98), lymphocyte (37.84±9.03), mixed leukocytes (10.00±3.51), platelets (244.02±62.32). (14.48±5.17 vs. 12.69±1.39 (43.01±3.89 38.97±3.45%), serum ferritin (115.4±74.3 69.20±12.36 total iron-binding capacity (316.84±1.38 320.95±41.01, P=0.01), iron (85.05±28.51 76.25±28.22, P=0.02) significantly lower women than men. Out 2,926 people who entered study, 195 (6.66%) suspected having thalassemia because their low MCV (71.61±7.33 fL) (MCH) (23.67±2.66 pg). Conclusion: relatively females awakens healthcare experts carefully examine these possibility minor after excluding other common possible reasons such as deficiency anemia studies electrophoresis.